Asset Details
Do you wish to reserve the book?
Graphene-based sensing of oxygen transport through pulmonary membranes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Graphene-based sensing of oxygen transport through pulmonary membranes
Do you wish to request the book?
Graphene-based sensing of oxygen transport through pulmonary membranes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Graphene-based sensing of oxygen transport through pulmonary membranes
2020
Overview
Lipid-protein complexes are the basis of pulmonary surfactants covering the respiratory surface and mediating gas exchange in lungs. Cardiolipin is a mitochondrial lipid overexpressed in mammalian lungs infected by bacterial pneumonia. In addition, increased oxygen supply (hyperoxia) is a pathological factor also critical in bacterial pneumonia. In this paper we fabricate a micrometer-size graphene-based sensor to measure oxygen permeation through pulmonary membranes. Combining oxygen sensing, X-ray scattering, and Atomic Force Microscopy, we show that mammalian pulmonary membranes suffer a structural transformation induced by cardiolipin. We observe that cardiolipin promotes the formation of periodic protein–free inter–membrane contacts with rhombohedral symmetry. Membrane contacts, or stalks, promote a significant increase in oxygen gas permeation which may bear significance for alveoli gas exchange imbalance in pneumonia.
Changes in the pulmonary membrane, caused by bacterial infection, form part of the pathology of pneumonia. Here, the authors report on a graphene-based oxygen sensor which is used along with X-ray diffraction and AFM to measure the structural changes and changes in oxygen permeability of pulmonary membranes associated with bacterial pneumonia.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Alveoli
/ Animals
/ Bacteria
/ Cell Membrane Permeability - physiology
/ Graphene
/ Humanities and Social Sciences
/ Humans
/ Lipids
/ Lungs
/ Mammals
/ Microscopy, Atomic Force - instrumentation
/ Microscopy, Confocal - instrumentation
/ Microtechnology - instrumentation
/ Oxygen
/ Pneumonia, Bacterial - physiopathology
/ Proteins
/ Pulmonary Alveoli - cytology
/ Pulmonary Alveoli - metabolism
/ Pulmonary Alveoli - ultrastructure
/ Pulmonary Gas Exchange - physiology
/ Science
