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The B-cell antigen receptor integrates adaptive and innate immune signals
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Journal Article
The B-cell antigen receptor integrates adaptive and innate immune signals
2015
Overview
B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
Adaptive Immunity - immunology
/ Animals
/ Antigens
/ Cell Proliferation - physiology
/ Electrophoretic Mobility Shift Assay
/ Immunity, Innate - immunology
/ Kinases
/ Mice
/ Phosphatidylinositol 3-Kinases - metabolism
/ Real-Time Polymerase Chain Reaction
/ Receptors, Antigen, B-Cell - immunology
