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Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains
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Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains
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Journal Article
Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains
2017
Overview
Antibiotic-resistant
Acinetobacter baumannii
is associated with nosocomial infections worldwide. Here, we used clinically isolated
A. baumannii
strains as models to demonstrate whether antibiotic resistance is correlated with an increased susceptibility to bacteriophages. In this study, 24 active phages capable of infecting
A. baumannii
were isolated from various environments, and the susceptibilities of both antibiotic-sensitive and antibiotic-resistant strains of
A. baumannii
to different phages were compared. In our study, a total of 403 clinically isolated
A. baumannii
strains were identified. On average, the phage infection percentage of the antibiotic-resistant
A. baumannii
strains was 84% (from 81–86%), whereas the infection percentage in the antibiotic-sensitive
A. baumannii
strains was only 56.5% (from 49–64%). In addition, the risk of phage infection for
A. baumannii
was significantly increased in the strains that were resistant to at least four antibiotics and exhibited a dose-dependent response (
p
-trend < 0.0001). Among all of the
A. baumannii
isolates, 75.6% were phage typeable. The results of phage typing might also reveal the antibiotic-resistant profiles of clinical
A. baumannii
strains. In conclusion, phage susceptibility represents an evolutionary trade-off in
A. baumannii
strains that show adaptations for antibiotic resistance, particularly in medical environments that have high antibiotic use.
Publisher
Springer Science and Business Media LLC,Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Acinetobacter baumannii - drug effects
/ Acinetobacter baumannii - growth & development
/ Acinetobacter baumannii - virology
/ Anti-Bacterial Agents - pharmacology
/ Bacteriophage Typing - methods
/ Drug Resistance, Multiple, Bacterial
/ Humanities and Social Sciences
/ Medicine
/ Phages
/ Q
/ R
/ Science
