Journal Article

Risk of de novo aneurysm formation in patients previously diagnosed with a ruptured or unruptured aneurysm: 18-year follow-up

Rentzos, Alexandros, Nilsson, Daniel, Karlsson, Adrian, Ståleby, Marcus, Rawshani, Araz, Samuelsson, Jennifer

2023

Overview

Data on de novo aneurysm formation after treatment for intracranial aneurysms remains scarce. We studied the incidence of de novo aneurysm formation in patients who had undergone aneurysm treatment more than 18 years prior to follow-up. As it is a disease affecting a younger patient population more specific guidelines are needed when planning a follow-up regime. The rate of de novo aneurysm formation was assessed with Magnetic Resonance Angiography (MRA) follow-up >18 years after endovascular or microsurgical treatment for an intracranial aneurysm. Variables associated with de novo aneurysm formation were studied using logistic regression. Missing data were imputed using chained random forests. A data-driven model for the prediction of de novo aneurysm was created to calculate the relative variable importance of ten clinical features. De novo aneurysms were identified in 11/81 (13.6 %) patients, of whom 1 was male, over a median follow-up of 20 years. Sex was the most important variable associated with de novo aneurysm formation. Regarding the development of de novo aneurysm, men displayed an odds ratio (OR) of 0.16 (0.01–0.97), compared with women. OR for mRS score 2 or more was 0.20 (95 % CI 0.01–1.34), and OR for smokers was 3.70 (0.54–31.18). Six out of 11 patients (54.5 %) needed treatment; 1 underwent endovascular treatment (EVT) and 5 underwent microsurgical treatment (MST). The overall annual de novo aneurysm formation rate was 0.92 %. This study highlights the need for a longer follow-up imaging monitoring of patients that have previously undergone treatment for an intracranial aneurysm. These data are useful to take into consideration when planning a follow-up strategy. •The overall annual de novo aneurysm formation rate was 0.92 %.•Sex was the most important variable associated with de novo aneurysm formation rate.•A longer follow-up is deemed necessary especially in the younger population suffering an aneurysmal Subarachnoid haemorrhage.

• Publisher: Elsevier B.V,Elsevier Limited
• Subject: Age / Aneurysm / Aneurysms / Angiography / Cardiovascular system / De novo aneurysm / diagnostic imaging / Electronic health records / Endovascular treatment / epidemiology / Female / Follow-Up Studies / Hemorrhage / Humans / Hypertension / Incidence / Intracranial Aneurysm / Kirurgi / Logistic Models / Long-term follow-up / Machine learning / Magnetic resonance imaging / Male / Medical imaging / Medical records / Microsurgical treatment / Missing data / Neurologi / Neurology / Neurosurgery / Patients / Radiologi och bildbehandling / Radiology and Medical Imaging / Risk Factors / Ruptured / Surgery / Treatment Outcome / Variables