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Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens
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Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens
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Journal Article
Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens
2017
Overview
Antibiotic resistance is becoming a pivotal concern for public health that has accelerated the search for new antimicrobial molecules from nature. Numbers of human pathogens have inevitably evolved to become resistant to various currently available drugs causing considerable mortality and morbidity worldwide. It is apparent that novel antibiotics are urgently warranted to combat these life-threatening pathogens. In recent years, there have been an increasing number of studies to discover new bioactive compounds from plant origin with the hope to control antibiotic-resistant bacteria. This review attempts to focus and record the plant-derived compounds and plant extracts against multi-drug-resistant (MDR) pathogens including methicillin-resistant
Staphylococcus aureus
(MRSA), MDR-
Mycobacterium tuberculosis
and malarial parasites
Plasmodium
spp. reported between 2005 and 2015. During this period, a total of 110 purified compounds and 60 plant extracts were obtained from 112 different plants. The plants reviewed in this study belong to 70 different families reported from 36 countries around the world. The present review also discusses the drug resistance in bacteria and emphasizes the urge for new drugs.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
