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Cap1–claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation
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Journal Article
Cap1–claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation
2014
Overview
Significance How the kidney handles chloride reabsorption has long been a mystery. Here, we have discovered a pathway in the kidney that utilizes channel-activating protease 1 and claudin-4 to physiologically regulate tight junction permeability to chloride. Such a pathway not only is important in renal regulation of chloride but also may play key roles in chloride transport across many other epithelia such as the lung, the salivary gland, and the skin. This discovery also attests to a concept of “druggable” tight junction. Proteases or protease-dependent mechanisms may be developed as pharmacological tools to transiently regulate tight junction permeability in the kidney, the intestine, and the blood–brain barrier.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Animals
/ Blood Pressure - drug effects
/ Cell Membrane - drug effects
/ Cell Membrane Permeability - drug effects
/ Humans
/ Kidney Tubules, Collecting - drug effects
/ Kidney Tubules, Collecting - metabolism
/ Kidneys
/ Mutation
/ Organ Specificity - drug effects
/ Protein Binding - drug effects
/ Protein Transport - drug effects
/ Recombinant Proteins - pharmacology
/ Renal Reabsorption - drug effects
/ RNA Interference - drug effects
/ Serine Endopeptidases - metabolism
/ Tissues
