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Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis
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Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis
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Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis
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Journal Article
Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis
2021
Overview
Objective To determine the effect of Ashwagandha extract on sleep. Methods A comprehensive search was conducted in CENTRAL, MEDLINE, SCOPUS, Google Scholars, World Health Organization Trials Portal, ClinicalTrials.gov, Clinical Trial Registry of India, and AYUSH Research Portal for all appropriate trials. Randomized controlled trials that examined the effect of Ashwagandha extract versus placebo on sleep in human participants 18 years old and above were considered. Two authors independently read all trials and independently extracted all relevant data. The primary outcomes were sleep quantity and sleep quality. The secondary outcomes were mental alertness on rising, anxiety level, and quality of life. Results A total of five randomized controlled trials containing 400 participants were analyzed. Ashwagandha extract exhibited a small but significant effect on overall sleep (Standardized Mean Difference -0.59; 95% Confidence Interval -0.75 to -0.42; I.sup.2 = 62%). The effects on sleep were more prominent in the subgroup of adults diagnosed with insomnia, treatment dosage [greater than or equal to]600 mg/day, and treatment duration [greater than or equal to]8 weeks. Ashwagandha extract was also found to improve mental alertness on rising and anxiety level, but no significant effect on quality of life. No serious side effects were reported. Conclusion Ashwagandha extract appears to has a beneficial effect in improving sleep in adults. However, data on the serious adverse effects of Ashwagandha extract are limited, and more safety data would be needed to assess whether it would be safe for long-term use.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Age
/ Anxiety
/ Insomnia
/ Medicine
/ Medicine and Health Sciences
/ Placebos
/ Research and Analysis Methods
/ Sleep
/ Stress
