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Continuous Positive Airway Pressure for Central Sleep Apnea and Heart Failure
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Journal Article
Continuous Positive Airway Pressure for Central Sleep Apnea and Heart Failure
2005
Overview
Central sleep apnea is common among patients who have heart failure and increases the risk of death in this setting. In the Canadian Continuous Positive Airway Pressure trial, continuous positive airway pressure (CPAP) therapy administered to patients with heart failure was found to reduce the severity of central sleep apnea and increase the left ventricular ejection fraction, but did not improve survival.
Continuous positive airway pressure therapy administered to patients with heart failure was found to reduce the severity of central sleep apnea and increase the left ventricular ejection fraction but did not improve survival.
Central sleep apnea, which is present in approximately 25 to 40 percent of patients with chronic heart failure,
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results from cyclic hyperventilation and falls in the partial pressure of arterial carbon dioxide below the apnea threshold.
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The condition affects cardiovascular function adversely by causing tissue hypoxia, arousals from sleep, and activation of the sympathetic nervous system, and it independently increases the risk of death.
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In short-term, single-center randomized trials lasting one to three months involving small numbers of patients who had central sleep apnea and chronic heart failure, continuous positive airway pressure (CPAP) attenuated the central sleep . . .
Publisher
Massachusetts Medical Society
