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Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation
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Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation
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Journal Article
Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation
2012
Overview
Transplanted individuals in operational tolerance (OT) maintain long-term stable graft function after completely stopping immunosuppression. Understanding the mechanisms involved in OT can provide valuable information about pathways to human transplantation tolerance. Here we report that operationally tolerant individuals display quantitative and functional preservation of the B-cell compartment in renal transplantation. OT exhibited normal numbers of circulating total B cells, naive, memory and regulatory B cells (Bregs) as well as preserved B-cell receptor repertoire, similar to healthy individuals. In addition, OT also displayed conserved capacity to activate the cluster of differentiation 40 (CD40)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in Bregs, in contrast, with chronic rejection. Rather than expansion or higher activation, we show that the preservation of the B-cell compartment favors OT.
Publisher
BioMed Central,Springer Nature B.V,Feinstein Institute for Medical Research,ScholarOne
Subject
/ Aged
/ Antigens
/ B-Lymphocytes, Regulatory - immunology
/ B-Lymphocytes, Regulatory - metabolism
/ Biomedical and Life Sciences
/ Female
/ Humans
/ Kidney Transplantation - immunology
/ Male
/ Receptors, Antigen, B-Cell - genetics
/ Receptors, Antigen, B-Cell - immunology
/ STAT3 Transcription Factor - metabolism
/ Surgery
