Journal Article

Activation of the renal GLP‐1R leads to expression of Ren1 in the renal vascular tree

Skovsted, Gry Freja, Ougaard, Maria Elm, Bjørnholm, Katrine Dahl, Pyke, Charles, Knudsen, Lotte Bjerre

2021

Overview

The GLP‐1 receptor (GLP‐1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP‐1R are elusive but may involve regulation of the renin‐angiotensin‐aldosterone system (RAAS). The expression of Ren1 in the mouse renal vasculature was investigated by in situ hybridization after a single subcutaneous dose of liraglutide, semaglutide and after repeated injections of liraglutide. Single and repeated exposure to GLP‐1R agonists induced expression of Ren1 in the renal vascular smooth muscle cell compartment compared with vehicle injected controls (p < .0001) for both semaglutide and liraglutide. The present data show a robust induction of Ren1 expression in the vascular smooth muscle cells of the kidney after single and repeated GLP‐1R activation and this renin recruitment may be involved in the effects of GLP‐1R agonist treatment on kidney disease. Single and repeated injections with long acting GLP‐1R agonists leads to induction of Ren1 transcription from VSMC in renal vasculature in mice.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
• Subject: Agonists / Animals / Blood pressure / Cell cycle / GLP‐1 / GLP‐1 receptor / GLP‐1R agonists / Glucagon-Like Peptide-1 Receptor - agonists / Hybridization / in situ hybridization / Kidney - metabolism / Kidneys / Liraglutide - metabolism / Liraglutide - pharmacology / Liraglutide - therapeutic use / Mice / Original / Original s / renal vasculature / Renin - metabolism / Renin - pharmacology / renin recruitment / Renin-Angiotensin System / Sodium / Stains & staining / Veins & arteries