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Remdesivir for the Treatment of Covid-19 — Final Report

by Green, Michelle , Osinusi, Anu , Oh, Myoung-don , Kalil, Andre C , Sweeney, Daniel A , Ohmagari, Norio , Creech, C. Buddy , Beigel, John H , Lane, H. Clifford , Zingman, Barry S , Hohmann, Elizabeth , Touloumi, Giota , Patterson, Thomas F , Kline, Susan , Luetkemeyer, Annie , Paredes, Roger , Burgess, Timothy H , Chu, Helen Y , Finberg, Robert W , Tapson, Victor , Nayak, Seema , Dodd, Lori E , Ruiz-Palacios, Guillermo M , Dierberg, Kerry , Short, William R , Fätkenheuer, Gerd , Neaton, James D , Bonnett, Tyler , Atmar, Robert L , Pett, Sarah , Lundgren, Jens , Babiker, Abdel G , Lye, David Chien , Mehta, Aneesh K , Hsieh, Lanny , Kortepeter, Mark G , Makowski, Mat , Tomashek, Kay M , Benfield, Thomas , Lopez de Castilla, Diego

in Adenosine Monophosphate - administration & dosage / Adenosine Monophosphate - adverse effects / Adenosine Monophosphate - analogs & derivatives / Adenosine Monophosphate - therapeutic use / Administration, Intravenous / Adult / Aged / Alanine - administration & dosage / Alanine - adverse effects / Alanine - analogs & derivatives / Alanine - therapeutic use / Allergies / Antiviral agents / Antiviral Agents - administration & dosage / Antiviral Agents - adverse effects / Antiviral Agents - therapeutic use / Antiviral drugs / Betacoronavirus / Clinical trials / Consent / Coronavirus Infections - drug therapy / Coronavirus Infections - mortality / Coronavirus Infections - therapy / Coronaviruses / COVID-19 / COVID-19 Drug Treatment / Disease / Double-Blind Method / Drug dosages / Drug therapy / Extracorporeal Membrane Oxygenation / Female / Hospitalization / Hospitals / Humans / Infectious diseases / Intravenous administration / Kaplan-Meier Estimate / Laboratories / Male / Middle Aged / Middle East respiratory syndrome / Mortality / Original / Oxygen Inhalation Therapy / Pandemics / Patients / Pneumonia, Viral - drug therapy / Pneumonia, Viral - mortality / Pneumonia, Viral - therapy / Respiration, Artificial / Respiratory diseases / Respiratory tract diseases / RNA polymerase / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Statistical analysis / Time Factors / Young Adult

2020

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Remdesivir for the Treatment of Covid-19 — Final Report

2020

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2020

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Journal Article

Remdesivir for the Treatment of Covid-19 — Final Report

Green, Michelle,

Osinusi, Anu,

Oh, Myoung-don,

Kalil, Andre C,

Sweeney, Daniel A,

Ohmagari, Norio,

Creech, C. Buddy,

Beigel, John H,

Lane, H. Clifford,

Zingman, Barry S,

Hohmann, Elizabeth,

Touloumi, Giota,

Patterson, Thomas F,

Kline, Susan,

Luetkemeyer, Annie,

Paredes, Roger,

Burgess, Timothy H,

Chu, Helen Y,

Finberg, Robert W,

Tapson, Victor,

Nayak, Seema,

Dodd, Lori E,

Ruiz-Palacios, Guillermo M,

Dierberg, Kerry,

Short, William R,

Fätkenheuer, Gerd,

Neaton, James D,

Bonnett, Tyler,

Atmar, Robert L,

Pett, Sarah,

Lundgren, Jens,

Babiker, Abdel G,

Lye, David Chien,

Mehta, Aneesh K,

Hsieh, Lanny,

Kortepeter, Mark G,

Makowski, Mat,

Tomashek, Kay M,

Benfield, Thomas,

Lopez de Castilla, Diego

2020

Overview

In this randomized, double-blind trial in 1062 adults hospitalized with Covid-19, remdesivir was superior to placebo in shortening the time to recovery (10 days, vs. 15 days with placebo). The estimates of mortality by day 29 were 11.4% with remdesivir and 15.2% with placebo. The benefit of remdesivir was most apparent in patients who were receiving low-flow oxygen at baseline.

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Publisher

Massachusetts Medical Society

Subject

Adenosine Monophosphate - administration & dosage

/ Adenosine Monophosphate - adverse effects

/ Adenosine Monophosphate - analogs & derivatives

/ Adenosine Monophosphate - therapeutic use

/ Administration, Intravenous

/ Adult

/ Aged