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Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery

by COPES, F , SABINO, L. B. de S , BRITO, E. S. de , LUIZ BRUNO DE SOUSA SABINO, UFC; FRANCESCO COPES, Laval University; SOLÈNE SAULAIS, Université du Québec à Montréal; EDY SOUSA DE BRITO, CNAT; IVANILDO JOSÉ DA SILVA JÚNIOR, UFC; TIEN CANH LE, Université du Québec à Montréal; MIRCEA ALEXANDRU MATEESCU, Université du Québec à Montréal; DIEGO MANTOVANI, Laval University , MANTOVANI, D , SAULAIS, S , MATEESCU, M. A , LE, T. C , SILVA JÚNIOR, I. J. da

in Analysis / Anthocyanin / anthocyanins / Antioxidants / bioactive agent delivery / Bioavailability / Biological activity / carboxymethyl starch / Fruits / Gastrointestinal system / Metabolism / Metabolites / monolithic tablets / Morphology / Scanning electron microscopy / Small intestine / Syzygium cumini

2022

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2022

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2022

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Journal Article

Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery

COPES, F,

SABINO, L. B. de S,

BRITO, E. S. de,

LUIZ BRUNO DE SOUSA SABINO, UFC; FRANCESCO COPES, Laval University; SOLÈNE SAULAIS, Université du Québec à Montréal; EDY SOUSA DE BRITO, CNAT; IVANILDO JOSÉ DA SILVA JÚNIOR, UFC; TIEN CANH LE, Université du Québec à Montréal; MIRCEA ALEXANDRU MATEESCU, Université du Québec à Montréal; DIEGO MANTOVANI, Laval University,

MANTOVANI, D,

SAULAIS, S,

MATEESCU, M. A,

LE, T. C,

SILVA JÚNIOR, I. J. da

2022

Overview

Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.

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Publisher

MDPI AG,MDPI

Subject

/ bioactive agent delivery

/ Bioavailability

/ Biological activity