Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Integrated proteomic analysis of post-translational modifications by serial enrichment

by Carr, Steven A , Jaffe, Jacob D , Qiao, Jana W , Mertins, Philipp , Gillette, Michael A , Burgess, Michael W , Udeshi, Namrata D , Patel, Jinal , Mani, D R , Clauser, Karl R

in 631/1647/2067 / 631/45/475 / 631/553 / 631/80/458 / Analysis / Bioinformatics / Biological Microscopy / Biological Techniques / Biomedical Engineering/Biotechnology / brief-communication / Cellular signal transduction / Gene expression / Gene Expression Profiling - methods / Leukemia / Life Sciences / Mass spectrometry / Mass Spectrometry - methods / Phosphorylation / Physiological aspects / Protein Processing, Post-Translational - physiology / Proteins / Proteome - metabolism / Proteomics / Systems Integration

2013

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Integrated proteomic analysis of post-translational modifications by serial enrichment

by Carr, Steven A , Jaffe, Jacob D , Qiao, Jana W , Mertins, Philipp , Gillette, Michael A , Burgess, Michael W , Udeshi, Namrata D , Patel, Jinal , Mani, D R , Clauser, Karl R

2013

Confirm

Do you wish to request the book?

Integrated proteomic analysis of post-translational modifications by serial enrichment

by Carr, Steven A , Jaffe, Jacob D , Qiao, Jana W , Mertins, Philipp , Gillette, Michael A , Burgess, Michael W , Udeshi, Namrata D , Patel, Jinal , Mani, D R , Clauser, Karl R

2013

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Integrated proteomic analysis of post-translational modifications by serial enrichment

Carr, Steven A,

Jaffe, Jacob D,

Qiao, Jana W,

Mertins, Philipp,

Gillette, Michael A,

Burgess, Michael W,

Udeshi, Namrata D,

Patel, Jinal,

Mani, D R,

Clauser, Karl R

2013

Overview

A mass spectrometry–based method using serial enrichments of different post-translational modifications (SEPTM) enables high-coverage proteomic analysis of multiple PTMs from a single biological sample. We report a mass spectrometry–based method for the integrated analysis of protein expression, phosphorylation, ubiquitination and acetylation by serial enrichments of different post-translational modifications (SEPTM) from the same biological sample. This technology enabled quantitative analysis of nearly 8,000 proteins and more than 20,000 phosphorylation, 15,000 ubiquitination and 3,000 acetylation sites per experiment, generating a holistic view of cellular signal transduction pathways as exemplified by analysis of bortezomib-treated human leukemia cells.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ 631/553

/ Biological Microscopy