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Advances in the development of N-glycopeptide enrichment materials based on hydrophilic interaction chromatography
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Journal Article
Advances in the development of N-glycopeptide enrichment materials based on hydrophilic interaction chromatography
2025
Overview
Protein glycosylation is one of the most important post-translational modifications, implicated in the development of various diseases, including neurodegenerative diseases, diabetes, and cancers. However, the low content of glycoproteins in biological samples, the diversity and heterogeneity of glycan structures, and insensitive detection methods make glycosylation analysis challenging. As a result, efficient enrichment of glycopeptides from complex samples is a critical step. Efficient enrichment technology can increase the abundance of intact N-glycopeptides in complex biological samples, thereby improving the sensitivity and coverage of glycosylation analysis, which is of great significance for the accurate identification of biomarkers and the development of glycopeptide-based drugs. Among various separation methods for N-glycopeptides, hydrophilic interaction chromatography has received increasing attention, and a variety of enrichment materials have been developed. This article classifies and describes the relevant hydrophilic interaction chromatography materials and provides a comprehensive review of their applications in N-glycopeptide enrichment regarding selectivity, sensitivity, and enrichment performance. Future development trends of ideal glycopeptide enrichment materials are also discussed.
Graphical Abstract
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V
Subject
/ Animals
/ Characterization and Evaluation of Materials
/ Chemistry and Materials Science
/ Chromatography, Liquid - methods
/ diabetes
/ Glycan
/ Glycopeptides - isolation & purification
/ Humans
/ hydrophilic interaction chromatography
/ Hydrophobic and Hydrophilic Interactions
