Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

A phase III randomized-controlled study of safety and immunogenicity of DTwP-HepB-IPV-Hib vaccine (HEXASIIL®) in infants

by Gairola, Sunil , Sharma, Inderjit , Khandgave, Prashant , Ravi, M. D. , Kawade, Anand , Jaganathan, K. S. , Pujari, Pramod , Kamath, Veena , Deshmukh, Bhaskar Jedhe , Gawande, Avinash , Desai, Shivani , Kulkarni, Ganesh , Vagha, Jayant , Lalwani, Sanjay , Thakkar, Pareshkumar , Ramanan, Padmasani Venkat , Gautam, Manish , Kumar, N. Ravi , Sharma, Hitt , Shewale, Sunil , Agarwal, Anurag , Rawal, Lalit , Kumar, Rakesh , Parekh, Sameer , Uttam, Kheya Ghosh , Tiple, Nishikant , Mahopatra, Jagannath , Dogar, Vikas , Tayade, Deepak

in 631/250/590 / 692/308/2779/109/1942 / 692/308/2779/777 / Antibodies / Antigens / Babies / Biomedical and Life Sciences / Biomedicine / Clinical trials / Diphtheria / Erythema / Hepatitis B / Immunity (Disease) / Immunogenicity / Infants / Infectious Diseases / Medical Microbiology / Patient safety / Pediatrics / Poliomyelitis / Public Health / Tetanus / Vaccine / Vaccines / Virology / Whooping cough

2024

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

A phase III randomized-controlled study of safety and immunogenicity of DTwP-HepB-IPV-Hib vaccine (HEXASIIL®) in infants

2024

Confirm

Do you wish to request the book?

A phase III randomized-controlled study of safety and immunogenicity of DTwP-HepB-IPV-Hib vaccine (HEXASIIL®) in infants

2024

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

A phase III randomized-controlled study of safety and immunogenicity of DTwP-HepB-IPV-Hib vaccine (HEXASIIL®) in infants

Gairola, Sunil,

Sharma, Inderjit,

Khandgave, Prashant,

Ravi, M. D.,

Kawade, Anand,

Jaganathan, K. S.,

Pujari, Pramod,

Kamath, Veena,

Deshmukh, Bhaskar Jedhe,

Gawande, Avinash,

Desai, Shivani,

Kulkarni, Ganesh,

Vagha, Jayant,

Lalwani, Sanjay,

Thakkar, Pareshkumar,

Ramanan, Padmasani Venkat,

Gautam, Manish,

Kumar, N. Ravi,

Sharma, Hitt,

Shewale, Sunil,

Agarwal, Anurag,

Rawal, Lalit,

Kumar, Rakesh,

Parekh, Sameer,

Uttam, Kheya Ghosh,

Tiple, Nishikant,

Mahopatra, Jagannath,

Dogar, Vikas,

Tayade, Deepak

2024

Overview

A fully liquid hexavalent containing Diphtheria (D), Tetanus (T) toxoids, whole cell Pertussis (wP), Hepatitis B (Hep B), type 1, 2, 3 of inactivated poliovirus (IPV) and Haemophilus influenzae type b (Hib) conjugate vaccine (DTwP-HepB-IPV-Hib vaccine, HEXASIIL ® ) was tested for lot-to-lot consistency and non-inferiority against licensed DTwP-HepB-Hib + IPV in an open label, randomized Phase II/III study. In Phase III part, healthy infants received DTwP-HepB-IPV-Hib or DTwP-HepB-Hib + IPV vaccines at 6, 10 and 14 weeks of age. Blood samples were collected prior to the first dose and 28 days, post dose 3. Non inferiority versus DTwP-HepB-Hib + IPV was demonstrated with 95% CIs for the treatment difference for seroprotection/seroconversion rates. For DTwP-HepB-IPV-Hib lots, limits of 95% CI for post-vaccination geometric mean concentration ratios were within equivalence limits (0.5 and 2). Vaccine was well-tolerated and no safety concerns observed. Clinical Trial Registration – CTRI/2019/11/022052

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

631/250/590

/ 692/308/2779/109/1942

/ 692/308/2779/777

/ Antibodies

/ Antigens

/ Babies

/ Biomedical and Life Sciences