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Pseudomonas Phage Lydia and the Evolution of the Mesyanzhinovviridae Family
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Pseudomonas Phage Lydia and the Evolution of the Mesyanzhinovviridae Family
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Journal Article
Pseudomonas Phage Lydia and the Evolution of the Mesyanzhinovviridae Family
2025
Overview
Phage Lydia, a newly isolated siphovirus infecting Pseudomonas aeruginosa, was characterized with respect to its basic kinetic properties and subjected to comparative bioinformatic analysis with related phages. The phage exhibited a restricted host range, with lytic activity observed against 7 of 30 tested isolates. The genome of phage Lydia consists of a 61,986 bp dsDNA molecule and contains 89 predicted genes. Bioinformatic analysis suggests the presence of a DNA modification system, but no apparent genes associated with lysogeny or antibiotic resistance were identified. Taxonomic classification places Lydia within the Mesyanzhinovviridae family, Rabinowitzvirinae subfamily, and Yuavirus genus, with the closest relation to Pseudomonas virus M6. Comprehensive bioinformatic studies, including structural modelling and analysis of phage proteins, as well as comparative taxonomic, phylogenomic, and pangenomic analyses of the Mesyanzhinovviridae family, revealed relationships between proteins of Mesyanzhinovviridae phages, proteins from other phage groups, encapsulins, and a gene transfer agent (GTA) particle from Rhodobacter capsulatus. These analyses uncovered patterns of evolutionary history within the family, characterized by genetic exchange events alongside the maintenance of a common genomic architecture, leading to the emergence of new groups within the family.
Publisher
MDPI AG,MDPI
Subject
/ Bacteria
/ Drug resistance in microorganisms
/ Enzymes
/ Genes
/ Genomes
/ Genomics
/ Lysogeny
/ phage
/ Phages
/ Proteins
/ Pseudomonas aeruginosa - virology
/ Pseudomonas Phages - classification
/ Pseudomonas Phages - genetics
/ Pseudomonas Phages - isolation & purification
/ Pseudomonas Phages - physiology
/ Siphoviridae - classification
/ Siphoviridae - isolation & purification
/ Taxonomy
