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MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization
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Journal Article
MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization
2018
Overview
The majority of the eukaryotic genome is transcribed into noncoding RNAs (ncRNAs), which are important regulators of different nuclear processes by controlling chromatin structure. However, the full extent of ncRNA function has remained elusive. Here we deciphered the function of the microRNA
Mirlet7d
as a key regulator of bidirectionally transcribed genes. We found that nuclear
Mirlet7d
binds ncRNAs expressed from these genes.
Mirlet7d
–ncRNA duplexes are further bound by C1D, which in turn targets the RNA exosome complex and the polycomb repressive complex 2 (PRC2) to the bidirectionally active loci. The exosome degrades the ncRNAs, whereas PRC2 induces heterochromatin and transcriptional silencing through EZH2. Moreover, this multicomponent RNA–protein complex, which we named MiCEE, tethers the regulated genes to the perinucleolar region and thus is required for proper nucleolar organization. Our study demonstrates that the MiCEE complex mediates epigenetic silencing of bidirectionally expressed genes and global genome organization.
The authors describe the MiCEE complex, which comprises
Mirlet7d
ncRNA duplexes bound by C1D, the RNA exosome complex, and PRC2. MiCEE regulates bidirectionally transcribed loci and nucleolar organization.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 38/32
/ 38/77
/ 45/15
/ 45/90
/ 45/91
/ 631/337
/ 82/58
/ 82/80
/ Animal Genetics and Genomics
/ Animals
/ Biomedical and Life Sciences
/ DNA
/ Exosomes
/ Genes
/ Genomes
/ Genomics
/ Heterochromatin - metabolism
/ Humans
/ Mice
/ MicroRNA
/ miRNA
/ Nucleoli
/ Nucleolus Organizer Region - genetics
/ Nucleolus Organizer Region - metabolism
/ Polycomb Repressive Complex 2 - genetics
/ Polycomb Repressive Complex 2 - metabolism
/ Proteins
/ RNA
/ RNA, Untranslated - genetics
/ RNA, Untranslated - metabolism
/ Tethers
