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Journal Article
Pernicious anemia presenting as glossitis
2020
Overview
Pernicious anemia is a macrocytic anemia caused by vitamin B12 deficiency that results from a lack of intrinsic factor. Lack of intrinsic factor may be caused by atrophic gastritis and damage to the oxyntic mucosa and parietal cells, which normally produce hydrochloric acid and intrinsic factor. Glossitis presents in up to 25% of people with pernicious anemia, initially as bright red plaques that may evolve into atrophy of the lingual papillae. Oral manifestations of pernicious anemia, including glossitis and stomatitis, may occur in the absence of anemia and represent an early clinical sign of vitamin B12 deficiency. Other causes of glossitis include nutritional deficiencies of vitamin B12, folic acid, riboflavin and niacin. Here, Kobayashi and Iwasaki examine the case of a 69-year-old Japanese woman with pernicious anemia.
Publisher
Elsevier Inc,CMA Impact, Inc,Joule Inc
