Journal Article

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

Blanck, Jean Philippe, Thompson-Snipes, LuAnn, Cantarel, Brandi L, Silver, Jonathan S, Ohne, Yoichiro, Copenhaver, Alan M, Liu, Yong-Jun, Collet, Magalie A, Humbles, Alison A

2016

Overview

Cytokines of the IL-1 family have a range of effects on innate lymphoid cells. Liu and colleagues find that IL-1 facilitates the maturation and plasticity of group 2 innate lymphoid cells. Group 2 innate lymphoid cells (ILC2 cells) are important for type 2 immune responses and are activated by the epithelial cytokines interleukin 33 (IL-33), IL-25 and thymic stromal lymphopoietin (TSLP). Here we demonstrated that IL-1β was a critical activator of ILC2 cells, inducing proliferation and cytokine production and regulating the expression of epithelial cytokine receptors. IL-1β also governed ILC2 plasticity by inducing low expression of the transcription factor T-bet and the cytokine receptor chain IL-12Rβ2, which enabled the conversion of these cells into an ILC1 phenotype in response to IL-12. This transition was marked by an atypical chromatin landscape characterized by the simultaneous transcriptional accessibility of the locus encoding interferon-γ (IFN-γ) and the loci encoding IL-5 and IL-13. Finally, IL-1β potentiated ILC2 activation and plasticity in vivo , and IL-12 acted as the switch that determined an ILC2-versus-ILC1 response. Thus, we have identified a previously unknown role for IL-1β in facilitating ILC2 maturation and plasticity.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 13/106 / 13/31 / 38/39 / 45/91 / 631/250/127/1213 / 631/250/2504/2506 / Animals / Biomedicine / Cell Differentiation / Cell Plasticity - immunology / Cells, Cultured / Cytokines - metabolism / Humans / Immunity, Innate / Immunology / Infectious Diseases / Interferon-gamma - metabolism / Interleukin-1 / Interleukin-12 - metabolism / Interleukin-17 - metabolism / Interleukin-1beta - metabolism / Interleukin-33 - metabolism / Lymphocytes - immunology / Lymphoid tissue / Mice / Mice, SCID / Phenotypic plasticity / Physiological aspects / Plasticity / Receptors, Interleukin-12 - genetics / Receptors, Interleukin-12 - metabolism / Signal Transduction / T-Box Domain Proteins - genetics / T-Box Domain Proteins - metabolism / Th1 Cells - immunology / Th1-Th2 Balance / Th2 Cells - immunology