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Metabolic differentiation in the embryonic retina
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Metabolic differentiation in the embryonic retina
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Journal Article
Metabolic differentiation in the embryonic retina
2012
Overview
It is unclear whether proliferating and differentiating cells produce energy through different metabolic pathways. Harris and colleagues show, in the embryonic
Xenopus
retina, that dividing progenitors use glycogen for glycolysis, and that a transition to oxidative phosphorylation occurs as cells differentiate.
Unlike healthy adult tissues, cancers produce energy mainly by aerobic glycolysis instead of oxidative phosphorylation
1
. This adaptation, called the Warburg effect, may be a feature of all dividing cells, both normal and cancerous
2
, or it may be specific to cancers
3
. It is not known whether, in a normally growing tissue during development, proliferating and postmitotic cells produce energy in fundamentally different ways. Here we show in the embryonic
Xenopus
retina
in vivo
, that dividing progenitor cells depend less on oxidative phosphorylation for ATP production than non-dividing differentiated cells, and instead use glycogen to fuel aerobic glycolysis. The transition from glycolysis to oxidative phosphorylation is connected to the cell differentiation process. Glycolysis is indispensable for progenitor proliferation and biosynthesis, even when it is not used for ATP production. These results suggest that the Warburg effect can be a feature of normal proliferation
in vivo
, and that the regulation of glycolysis and oxidative phosphorylation is critical for normal development.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
