Journal Article

Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI

Biessels, Geert Jan, Zwanenburg, Jaco J.M., Sloots, Jacob Jan

2020

Overview

Microvascular blood volume pulsations due to the cardiac and respiratory cycles induce brain tissue deformation and, as such, are considered to drive the brain’s waste clearance system. We have developed a high-field magnetic resonance imaging (MRI) technique to quantify both cardiac and respiration-induced tissue deformations, which could not be assessed noninvasively before. The technique acquires motion encoded snapshot images in which various forms of motion and confounders are entangled. First, we optimized the motion sensitivity for application in the human brain. Next, we isolated the heartbeat and respiration-related deformations, by introducing a linear model that fits the snapshot series to the recorded physiological information. As a result, we obtained maps of the physiological tissue deformation with 3mm isotropic spatial resolution. Heartbeat and respiration-induced volumetric strain were significantly different from zero in the basal ganglia (median (25–75% interquartile range): 0.85·10−3 (0.39·10−3–1.05·10−3), p ​= ​0.0008 and −0.28·10−3 (−0.41·10−3–0.06·10−3), p ​= ​0.047, respectively. Smaller volumetric strains were observed in the white matter of the centrum semi ovale (0.28·10−3 (0–0.59·10−3) and −0.06·10−3 (−0.17·10−3–0.20·10−3)), which was only significant for the heartbeat (p ​= ​0.02 and p ​= ​0.7, respectively). Furthermore, heartbeat-induced volumetric strain was about three times larger than respiration-induced volumetric strain. This technique opens a window on the driving forces of the human brain clearance system. •Cardiac and respiration-induced brain deformations simultaneously measured with MRI.•Single-shot 2D DENSE is suitable to unravel cardiac and respiration induced brain tissue strain.•Tissue deformation of the brain is mainly driven by the cardiac cycle.•Inspiration induces tissue compression, probably due to venous outflow.

• Publisher: Elsevier Inc,Elsevier Limited,Elsevier
• Subject: Adult / Basal ganglia / Blood / Brain / Brain - diagnostic imaging / Brain - physiology / Datasets / Deformation / Female / Heart / Heart Rate - physiology / Humans / Magnetic resonance imaging / Magnetic Resonance Imaging - methods / Magnetic Resonance Imaging - standards / Male / Microvasculature / Models, Theoretical / Neuroimaging / Neuroimaging - methods / Neuroimaging - standards / Physiology / Respiration / Single-shot DENSE / Small vessel disease / Spatial discrimination / Substantia alba / Tissue strain / Waste clearance