Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline

by Melo Ferreira, Ricardo , Hato, Takashi , Liu, Yun-Long , El-Achkar, Tarek M , Collins, Kimberly S , Maier, Bernhard , McCarthy, Thomas W , Dagher, Pierre C , Xuei, Xiaoling , Gao, Hongyu , Eadon, Michael T , Zollman, Amy , Winfree, Seth , Syed, Farooq , Cheng, Ying-Hua , Myslinski, Jered , Janosevic, Danielle

in acute kidney injury / Adult / Aged / Animals / Cell cycle / Cell interactions / Dendritic cells / Endotoxemia / Endotoxemia - etiology / Endotoxins - metabolism / Epithelial cells / First responders / Gene expression / Homeostasis / Humans / Immunology and Inflammation / Kidney - metabolism / Kidneys / Lymphocytes / Male / Medicine / Mice / Mice, Inbred C57BL / Middle Aged / Neutrophils / Paralysis / Pathophysiology / Sepsis / Sepsis - etiology / single-cell RNA-seq / Stromal cells / Young Adult

2021

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline

2021

Confirm

Do you wish to request the book?

The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline

2021

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline

Melo Ferreira, Ricardo,

Hato, Takashi,

Liu, Yun-Long,

El-Achkar, Tarek M,

Collins, Kimberly S,

Maier, Bernhard,

McCarthy, Thomas W,

Dagher, Pierre C,

Xuei, Xiaoling,

Gao, Hongyu,

Eadon, Michael T,

Zollman, Amy,

Winfree, Seth,

Syed, Farooq,

Cheng, Ying-Hua,

Myslinski, Jered,

Janosevic, Danielle

2021

Overview

Sepsis is a dynamic state that progresses at variable rates and has life-threatening consequences. Staging patients along the sepsis timeline requires a thorough knowledge of the evolution of cellular and molecular events at the tissue level. Here, we investigated the kidney, an organ central to the pathophysiology of sepsis. Single-cell RNA-sequencing in a murine endotoxemia model revealed the involvement of various cell populations to be temporally organized and highly orchestrated. Endothelial and stromal cells were the first responders. At later time points, epithelial cells upregulated immune-related pathways while concomitantly downregulating physiological functions such as solute homeostasis. Sixteen hours after endotoxin, there was global cell–cell communication failure and organ shutdown. Despite this apparent organ paralysis, upstream regulatory analysis showed significant activity in pathways involved in healing and recovery. This rigorous spatial and temporal definition of murine endotoxemia will uncover precise biomarkers and targets that can help stage and treat human sepsis.

Share this book

Add to My Shelf

Publisher

eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd

Subject

acute kidney injury

/ Adult

/ Aged

/ Animals

/ Cell cycle

/ Cell interactions

/ Dendritic cells