Journal Article

Late-Onset Ocular Hypotensive Effect of Ripasudil on Primary Open-Angle Glaucoma

Nakano, Tadashi, Ogawa, Shumpei, Tatemichi, Masayuki, Sano, Kei, Fukai, Kota, Noro, Takahiko, Terauchi, Ryo

2024

Overview

We evaluated the late-onset ocular hypotensive effect of ripasudil after long-term administration in real-world clinical data and investigated its associated factors in primary open-angle glaucoma (POAG). We reviewed the clinical patients with POAG who newly started ripasudil without changes of treatment. Enrolled eyes were assigned to two groups: positive group with the late-onset effect and negative group. Eyes that show the late-onset effect 6 months after starting ripasudil were defined as positive. Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the late-onset effect. We enrolled 74 eyes of 74 patients with POAG (age, 67.5 ± 10.9 years; mean deviation, -11.2 ± 5.9 dB) and followed them for 14.2 ± 5.0 months. Among them, 12 (16.2%) eyes were assigned to the positive group. Retinal nerve fiber layer (RNFL) thickness (73.4 ± 12.9 vs 64.0 ± 9.8 μm, = 0.04) and primary IOP (18.8 ± 4.1 vs 15.8 ± 4.3 mmHg, = 0.01) before starting ripasudil were higher in the positive group than in the negative group. The late-onset effect was associated with higher IOP (OR, 1.22; 1.01-1.48) and thicker RNFL (2.76; 1.15-6.63). Some patients with POAG showed the late-onset IOP-lowering effect of ripasudil, and its associated factors were higher IOP and thicker RNFL. The addition of ripasudil may offer potential benefits particularly for early-stage glaucoma with thicker RNFL.

• Publisher: Dove Medical Press Limited,Taylor & Francis Ltd,Dove Press,Dove,Dove Medical Press
• Subject: Care and treatment / Glaucoma / Hypertension / intraocular pressure / Kinases / Medical colleges / ocular hypertension / Open-angle glaucoma / Original Research / Patients / Regression analysis / ripasudil / ROCK-inhibitor / Trends / Visual acuity