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Nlrp6 regulates intestinal antiviral innate immunity
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Journal Article
Nlrp6 regulates intestinal antiviral innate immunity
2015
Overview
The nucleotide-binding oligomerization domain-like receptor (Nlrp) 6 maintains gut microbiota homeostasis and regulates antibacterial immunity. We now report a role for Nlrp6 in the control of enteric virus infection. Nlrp6-/- and control mice systemically challenged with encephalomyocarditis virus had similar mortality; however, the gastrointestinal tract of Nlrp6-/- mice exhibited increased viral loads. Nlrp6-/- mice orally infected with encephalomyocarditis virus had increased mortality and viremia compared with controls. Similar results were observed with murine norovirus 1. Nlrp6 bound viral RNA via the RNA helicase Dh×15 and interacted with mitochondrial antiviral signaling protein to induce type I/III interferons (IFNs) and IFN-stimulated genes (ISGs). These data demonstrate that Nlrp6 functions with Dh×15 as a viral RNA sensor to induce ISGs, and this effect is especially important in the intestinal tract.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Attrition (Research Studies)
/ Caliciviridae Infections - immunology
/ Caliciviridae Infections - virology
/ Cardiovirus Infections - immunology
/ Cardiovirus Infections - virology
/ Encephalomyocarditis virus - immunology
/ Gastroenteritis - immunology
/ Humans
/ Immunity
/ Interferon Type I - immunology
/ Mice
/ Proteins
/ Receptors, Cell Surface - genetics
/ Receptors, Cell Surface - physiology
/ Viruses
