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Morning resting hypothalamus-dorsal striatum connectivity predicts individual differences in diurnal sleepiness accumulation
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Morning resting hypothalamus-dorsal striatum connectivity predicts individual differences in diurnal sleepiness accumulation
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Journal Article
Morning resting hypothalamus-dorsal striatum connectivity predicts individual differences in diurnal sleepiness accumulation
2024
Overview
•This study identifies the individual differences in the accumulation of subjective daytime sleepiness by mathematical modeling.•This study reveals the crucial role of hypothalamus-dorsal striatum connectivity in predicting individual variations in daytime sleepiness, as indicated by resting-state fMRI analysis and behavioral assessments using the Karolinska Sleepiness Scale.•The findings highlight the distinct contributions of hypothalamic connections to different parts of the striatum, with the hypothalamus-dorsal striatum circuit identified as a potential target for interventions aimed at reducing excessive sleepiness and enhancing daytime alertness.
While the significance of obtaining restful sleep at night and maintaining daytime alertness is well recognized for human performance and overall well-being, substantial variations exist in the development of sleepiness during diurnal waking periods. Despite the established roles of the hypothalamus and striatum in sleep-wake regulation, the specific contributions of this neural circuit in regulating individual sleep homeostasis remain elusive. This study utilized resting-state functional magnetic resonance imaging (fMRI) and mathematical modeling to investigate the role of hypothalamus-striatum connectivity in subjective sleepiness variation in a cohort of 71 healthy adults under strictly controlled in-laboratory conditions. Mathematical modeling results revealed remarkable individual differences in subjective sleepiness accumulation patterns measured by the Karolinska Sleepiness Scale (KSS). Brain imaging data demonstrated that morning hypothalamic connectivity to the dorsal striatum significantly predicts the individual accumulation of subjective sleepiness from morning to evening, while no such correlation was observed for the hypothalamus-ventral striatum connectivity. These findings underscore the distinct roles of hypothalamic connectivity to the dorsal and ventral striatum in individual sleep homeostasis, suggesting that hypothalamus-dorsal striatum circuit may be a promising target for interventions mitigating excessive sleepiness and promoting alertness.
Publisher
Elsevier Inc,Elsevier Limited,Elsevier
Subject
/ Behavior
/ Circadian Rhythm - physiology
/ Corpus Striatum - diagnostic imaging
/ Corpus Striatum - physiology
/ Diurnal
/ Female
/ Functional magnetic resonance imaging
/ Humans
/ Hypothalamus - diagnostic imaging
/ Male
/ Neural Pathways - diagnostic imaging
/ Neural Pathways - physiology
/ Resting-state functional connectivity
/ Sleep
