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Antimicrobial properties of the novel bacterial isolate Paenibacilllus sp. SMB1 from a halo-alkaline lake in India
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Antimicrobial properties of the novel bacterial isolate Paenibacilllus sp. SMB1 from a halo-alkaline lake in India
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Journal Article
Antimicrobial properties of the novel bacterial isolate Paenibacilllus sp. SMB1 from a halo-alkaline lake in India
2019
Overview
Antibiotic-resistance is ever growing burden on our society for the past many years. Many synthetic chemistry approaches and rational drug-design have been unable to pace up and tackle this problem. Natural resources, more specifically, the microbial diversity, on the other hand, make a traditional and still the best platform to search for new chemical scaffolds and compounds. Here, we report the antimicrobial characteristics of novel bacterial isolate from a salt lake in India. We screened the bacterial isolates for their inhibitory activity against indicator bacteria and found that four novel species were able to prevent the growth of test strains studied
in vitro
. Further, we characterized one novel species (SMB1
T
= SL4-2) using polyphasic taxonomic approaches and also purified the active ingredient from this bacterium. We successfully characterized the antimicrobial compound using mass spectroscopy and amino acid analysis. We also allocated two novel biosynthetic gene clusters for putative bacteriocins and one novel non-ribosomal peptide gene cluster in its whole genome. We concluded that the strain SMB1
T
belonged to the genus
Paenibacilllus
with the pairwise sequence similarity of 98.67% with
Paenibacillus tarimensis
DSM 19409
T
and we proposed the name
Paenibacillus sambharensis
sp. nov. The type strain is SMB1
T
(=MTCC 12884 = KCTC 33895
T
).
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 82
/ 82/16
/ 82/58
/ 82/83
/ Anti-Infective Agents - chemistry
/ Anti-Infective Agents - isolation & purification
/ Anti-Infective Agents - metabolism
/ Anti-Infective Agents - pharmacology
/ Bacillus subtilis - drug effects
/ Bacteria
/ Candida albicans - drug effects
/ Escherichia coli - drug effects
/ Escherichia coli Infections - drug therapy
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ India
/ Paenibacillus - isolation & purification
/ Peptides
/ Science
/ Taxonomy
