Asset Details
Do you wish to reserve the book?
RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism
Do you wish to request the book?
RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism
2025
Overview
Cancer cells rely on mitochondria for their bioenergetic supply and macromolecule synthesis. Central to mitochondrial function is the regulation of mitochondrial protein synthesis, which primarily depends on the cytoplasmic translation of nuclear-encoded mitochondrial mRNAs whose protein products are imported into mitochondria. Despite the growing evidence that mitochondrial protein synthesis contributes to the onset and progression of cancer, and can thus offer new opportunities for cancer therapy, knowledge of the underlying molecular mechanisms remains limited. Here, we show that RNA G-quadruplexes (RG4s) regulate mitochondrial function by modulating cytoplasmic mRNA translation of nuclear-encoded mitochondrial proteins. Our data support a model whereby the RG4 folding dynamics, under the control of oncogenic signaling and modulated by small molecule ligands or RG4-binding proteins, modifies mitochondria-localized cytoplasmic protein synthesis. Ultimately, this impairs mitochondrial functions, affecting energy metabolism and consequently cancer cell proliferation.
Cancer cells rely on mitochondria for energy and macromolecule synthesis. Here, the authors show that RNA G-quadruplex dynamics, driven by oncogenic signals, regulate the translation of nuclear-encoded mitochondrial mRNAs, affecting mitochondrial function and promoting cancer cell growth.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/34
/ 14/63
/ 38/1
/ 38/109
/ 38/32
/ 38/39
/ 38/43
/ 38/77
/ 38/88
/ 38/89
/ 38/90
/ 38/91
/ 631/337
/ 82/58
/ 82/80
/ Biochemistry, Molecular Biology
/ Cancer
/ Energy Metabolism - genetics
/ Humanities and Social Sciences
/ Humans
/ Mitochondrial Proteins - genetics
/ Mitochondrial Proteins - metabolism
/ mRNA
/ Proteins
/ Science
