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Classical pituitary tumour apoplexy: Clinical features, management and outcomes in a series of 24 patients
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Classical pituitary tumour apoplexy: Clinical features, management and outcomes in a series of 24 patients
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Journal Article
Classical pituitary tumour apoplexy: Clinical features, management and outcomes in a series of 24 patients
2007
Overview
We retrospectively analysed the incidence, clinical presentation, endocrinological and radiological findings, medical and surgical management of pituitary apoplexy in our department (single-centre study), having a large experience in pituitary surgery.
Among 1540 pituitary lesions, 24 patients presented with pituitary apoplexy. Their charts were retrospectively reviewed. The symptoms included headache (92%), nausea and vomiting (54%), visual deficit (50%), oculomotor paresis (54%) and/or an altered mental state (42%). Skull X-rays (
n
=
14) demonstrated an enlarged sella turcica in all cases; CT-scan and/or MRI always revealed a sellar and suprasellar expanding lesion. Panhypopituitarism was present on admission in 70% of the patients. Urgent therapeutic management included high-dose cortisone treatment in all but one patients and CSF drainage in three. Three patients were treated conservatively. Nine patients were operated on rapidly, within hours or a few days because of severe visual deficit and/or altered level of consciousness. Nineteen patients were operated by the trans-sphenoidal approach; one of them required a second operation by craniotomy. There were two deaths related to the illness and one to an ill-defined reason at 4 months. Among the other patients 95% made a good recovery. All but two patients required a substitutive treatment with adrenal (83%), thyroid (68%), gonadal (42%) and/or growth (16%) hormones. The preoperative visual deficits recovered in all but one patients (92%) whereas the oculomotor pareses improved in all but two patients (85%).
In conclusion, pituitary tumour apoplexy is a rare event, complicating in our series 1.6% of 1540 pituitary adenomas. Even in severe cases, complete recovery is possible if the diagnosis is rapidly obtained and adequate management is initiated in time. Surgical results after trans-sphenoidal approach are in the majority of cases very satisfactory.
Publisher
Elsevier B.V,Elsevier Science,Elsevier Limited,Elsevier
Subject
/ Adult
/ Aged
/ Biological and medical sciences
/ Endocrinologie, métabolisme & nutrition
/ Endocrinology, metabolism & nutrition
/ Female
/ Humans
/ Male
/ Pituitary Apoplexy - diagnosis
/ Pituitary Apoplexy - etiology
/ Pituitary Apoplexy - therapy
/ Pituitary Apoplexy/diagnosis/etiology/therapy
/ Pituitary Neoplasms - pathology
/ Sciences de la santé humaine
/ Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
