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A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors
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A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors
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Journal Article
A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors
2025
Overview
Small nucleolar RNAs are non-coding transcripts that guide chemical modifications of RNA substrates and modulate gene expression at the epigenetic and post-transcriptional levels. However, the extent of their regulatory potential and the underlying molecular mechanisms remain poorly understood. Here, we identify a conserved, previously unannotated intronic C/D-box snoRNA, termed
snR107
, hosted in the fission yeast long non-coding RNA
mamRNA
and carrying two independent cellular functions. On the one hand,
snR107
guides site-specific 25S rRNA 2’-O-methylation and promotes pre-rRNA processing and 60S subunit biogenesis. On the other hand,
snR107
associates with the gametogenic RNA-binding proteins Mmi1 and Mei2, mediating their reciprocal inhibition and restricting meiotic gene expression during sexual differentiation. Both functions require distinct
cis
-motifs within
snR107
, including a conserved 2’-O-methylation guiding sequence. Together, our results position
snR107
as a dual regulator of rRNA modification and gametogenesis effectors, expanding our vision on the non-canonical functions exerted by snoRNAs in cell fate decisions.
Small nucleolar RNAs (snoRNAs) are known for their role in RNA modification to regulate gene expression. Here, the authors identify a snoRNA that not only guides ribosomal RNA 2’- O-methylation but also modulates the activities of RNA-binding proteins involved in fission yeast gametogenesis.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/32
/ 38/39
/ 38/71
/ 38/88
/ 38/90
/ 38/91
/ 82/29
/ Binding
/ Fission
/ Gene Expression Regulation, Fungal
/ Humanities and Social Sciences
/ Meiosis
/ mRNA Cleavage and Polyadenylation Factors
/ Nucleoli
/ Proteins
/ RNA
/ RNA Processing, Post-Transcriptional
/ RNA, Long Noncoding - genetics
/ RNA, Long Noncoding - metabolism
/ RNA, Small Nucleolar - genetics
/ RNA, Small Nucleolar - metabolism
/ RNA-Binding Proteins - genetics
/ RNA-Binding Proteins - metabolism
/ rRNA
/ rRNA 25S
/ Schizosaccharomyces - genetics
/ Schizosaccharomyces - metabolism
/ Schizosaccharomyces pombe Proteins - genetics
/ Schizosaccharomyces pombe Proteins - metabolism
/ Science
/ snoRNA
/ Yeast
