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Comprehensive genome catalog analysis of the resistome, virulome and mobilome in the wild rodent gut microbiota
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Comprehensive genome catalog analysis of the resistome, virulome and mobilome in the wild rodent gut microbiota
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Journal Article
Comprehensive genome catalog analysis of the resistome, virulome and mobilome in the wild rodent gut microbiota
2025
Overview
Wild rodent’s gut microbiota serves as a crucial reservoir of antibiotic resistance genes (ARGs), where antimicrobial-resistant bacteria interact with mobile genetic elements (MGEs) to facilitate horizontal gene transfer. This study analyzed 12,255 gut-derived bacterial genomes from wild rodents to characterize the distribution of ARGs and virulence factor genes (VFGs), and to identify their bacterial hosts. A total of 8119 ARGs and 7626 VFGs were identified. The most prevalent ARGs conferred resistance to elfamycin, followed by those associated with multi-class antibiotic resistance.
Enterobacteriaceae
, particularly
Escherichia coli
, harbored the highest numbers of ARGs and VFGs. A strong correlation between the presence of MGEs, ARGs, and VFGs was observed, highlighting the potential for co-selection and mobilization of resistance and virulence traits. These findings underscore the importance of expanded surveillance to monitor and mitigate the risk of transmission of resistant and potentially pathogenic bacteria from wild rodents to human and animal populations.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/326
/ Animals
/ Animals, Wild - microbiology
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Bacteria - isolation & purification
/ Biofilms
/ Biomedical and Life Sciences
/ Drug Resistance, Bacterial - genetics
/ Gastrointestinal Microbiome - genetics
/ Genes
/ Genomes
/ Interspersed Repetitive Sequences
/ Microbial Genetics and Genomics
/ Multidrug resistant organisms
/ Peptides
/ Rodents
/ Taxonomy
