Journal Article

Cortisol disrupts the neural correlates of extinction recall

Merz, Christian J., Lissek, Silke, Kinner, Valerie L., Wolf, Oliver T.

2016

Overview

The renewal effect describes the recovery of extinguished responses that may occur after a change in context and indicates that extinction memory retrieval is sometimes prone to failure. Stress hormones have been implicated to modulate extinction processes, with mostly impairing effects on extinction retrieval. However, the neurobiological mechanisms mediating stress effects on extinction memory remain elusive. In this functional magnetic resonance imaging study, we investigated the effects of cortisol administration on the neural correlates of extinction memory retrieval in a predictive learning task. In this task, participants were required to predict whether certain food stimuli were associated with stomach trouble when presented in two different contexts. A two-day renewal paradigm was applied in which an association was acquired in context A and subsequently extinguished in context B. On the following day, participants received either cortisol or placebo 40min before extinction memory retrieval was tested in both contexts. Behaviorally, cortisol impaired the retrieval of extinguished associations when presented in the extinction context. On the neural level, this effect was characterized by a reduced context differentiation for the extinguished stimulus in the ventromedial prefrontal cortex, but only in men. In the placebo group, ventromedial prefrontal cortex was functionally connected to the left cerebellum, the anterior cingulate and the right anterior parahippocampal gyrus to express extinction memory. This functional crosstalk was reduced under cortisol. These findings illustrate that the stress hormone cortisol disrupts ventromedial prefrontal cortex functioning and its communication with other brain regions implicated in extinction memory. •Extinction retrieval was studied using a predictive learning task.•The stress hormone cortisol impaired extinction retrieval.•Cortisol reduced differential neural activity in the vm PFC.•Cortisol disrupted the functional connectivity of the vmPFC.

• Publisher: Elsevier Inc,Elsevier Limited
• Subject: Adolescent / Adult / Association Learning - drug effects / Association Learning - physiology / Brain Mapping - methods / Extinction recall / Extinction, Psychological - drug effects / Extinction, Psychological - physiology / Female / Functional connectivity / Functional magnetic resonance imaging / Humans / Hydrocortisone - administration & dosage / Localization / Male / Medical imaging / Mental Recall - physiology / Mental Recall - radiation effects / Nerve Net - drug effects / Nerve Net - physiology / Prefrontal Cortex - drug effects / Prefrontal Cortex - physiology / Renewal effect / Rodents / Sex differences / Stress hormones / Studies / Women / Young Adult