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First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness
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First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness
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Journal Article
First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness
2018
Overview
Protontherapy is hadrontherapy’s fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy’s superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer)
12
C-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper
12
C-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p +
11
B → 3α reaction to generate high-LET alpha particles with a clinical proton beam. To maximize the reaction rate, we used sodium borocaptate (BSH) with natural boron content. Boron-Neutron Capture Therapy (BNCT) uses
10
B-enriched BSH for neutron irradiation-triggered alpha particles. We recorded significantly increased cellular lethality and chromosome aberration complexity. A strategy combining protontherapy’s ballistic precision with the higher RBE promised by BNCT and
12
C-ion therapy is thus demonstrated.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/2
/ 631/57
/ Alpha Particles - therapeutic use
/ Animals
/ Boron
/ Boron Neutron Capture Therapy - instrumentation
/ Boron Neutron Capture Therapy - methods
/ Cancer
/ Cell Death - radiation effects
/ Chromosome Aberrations - radiation effects
/ Combined Modality Therapy - instrumentation
/ Combined Modality Therapy - methods
/ DNA
/ DNA, Neoplasm - radiation effects
/ Dose-Response Relationship, Radiation
/ Fluorescent Dyes - chemistry
/ Humanities and Social Sciences
/ Humans
/ Male
/ Neutrons
/ Photons
/ Prostatic Neoplasms - pathology
/ Prostatic Neoplasms - radiotherapy
/ Proton Therapy - instrumentation
/ Protons
/ Relative Biological Effectiveness
/ Science
/ Sodium
/ Sulfhydryl Compounds - chemistry
/ Tumors
