Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis

by Razjouyan, Javad , Bergquist, Annika , McGlynn, Katherine A. , Lee, Hyun-Sung , Cooley, Matthew A. , Franke, Andre , Ellinghaus, David , Hassan, Manal M. , Amos, Christopher I. , Zhu, Catherine , Rushbrook, Simon M. , Karlsen, Tom H. , Han, Younghun , Shaw, Vikram R. , Siminovitch, Katherine A. , Sun, Ryan , Folseraas, Trine , Lazaridis, Konstantinos N. , Byun, Jinyoung , Cordell, Heather J. , Kang, Sung Wook , Roberts, Lewis R. , Roh, Julia Y.

in 45/43 / 631/208/205/2138 / 631/208/726/649 / 631/208/727/2000 / Annotations / Bile ducts / Cholangitis / Cholangitis, Sclerosing / Drug development / Drug efficacy / Epidemiology / Etiology / Gene mapping / Genome-wide association studies / Genome-Wide Association Study / Genomes / Humanities and Social Sciences / Humans / Immunosuppressive agents / Interferon Regulatory Factors - genetics / multidisciplinary / Phenotype / Polymorphism, Single Nucleotide / Science / Science (multidisciplinary) / Therapeutic targets

2023

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis

2023

Confirm

Do you wish to request the book?

Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis

2023

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis

Razjouyan, Javad,

Bergquist, Annika,

McGlynn, Katherine A.,

Lee, Hyun-Sung,

Cooley, Matthew A.,

Franke, Andre,

Ellinghaus, David,

Hassan, Manal M.,

Amos, Christopher I.,

Zhu, Catherine,

Rushbrook, Simon M.,

Karlsen, Tom H.,

Han, Younghun,

Shaw, Vikram R.,

Siminovitch, Katherine A.,

Sun, Ryan,

Folseraas, Trine,

Lazaridis, Konstantinos N.,

Byun, Jinyoung,

Cordell, Heather J.,

Kang, Sung Wook,

Roberts, Lewis R.,

Roh, Julia Y.

2023

Overview

Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly associated with immune-mediated disorders. In this study, we implemented multitrait joint analyses to genome-wide association summary statistics of PSC and numerous clinical and epidemiological traits to estimate the genetic contribution of each trait and genetic correlations between traits and to identify new lead PSC risk-associated loci. We identified seven new loci that have not been previously reported and one new independent lead variant in the previously reported locus. Functional annotation and fine-mapping nominated several potential susceptibility genes such as MANBA and IRF5 . Network-based in silico drug efficacy screening provided candidate agents for further study of pharmacological effect in PSC. The genetic basis of primary sclerosing cholangitis has only been partially uncovered. Here, the authors perform a multitrait genome-wide association study to provide insight into the genetic etiology of primary sclerosing cholangitis risk and possible therapeutic drug targets.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject