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A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens
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A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens
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A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens
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Journal Article
A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens
2017
Overview
Both land plants and metazoa have the capacity to reprogram differentiated cells to stem cells. Here we show that the moss
Physcomitrella patens
Cold-Shock Domain Protein 1 (PpCSP1) regulates reprogramming of differentiated leaf cells to chloronema apical stem cells and shares conserved domains with the induced pluripotent stem cell factor Lin28 in mammals. PpCSP1 accumulates in the reprogramming cells and is maintained throughout the reprogramming process and in the resultant stem cells. Expression of
PpCSP1
is negatively regulated by its 3′-untranslated region (3′-UTR). Removal of the 3′-UTR stabilizes
PpCSP1
transcripts, results in accumulation of PpCSP1 protein and enhances reprogramming. A quadruple deletion mutant of
PpCSP1
and three closely related
PpCSP
genes exhibits attenuated reprogramming indicating that the
PpCSP
genes function redundantly in cellular reprogramming. Taken together, these data demonstrate a positive role of PpCSP1 in reprogramming, which is similar to the function of mammalian Lin28.
Land plants and metazoans are both able to reprogram differentiated cells to stem cells under certain circumstances. Here the authors show that the moss CSP1 protein, which shares conserved domains with the mammalian pluripotent stem cell factor Lin28, promotes reprogramming of leaf cells to apical stem cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/100
/ 14
/ 14/35
/ 3' Untranslated Regions - physiology
/ 38
/ 38/91
/ 64
/ Bacteria
/ Biology
/ Cell Differentiation - physiology
/ Cellular Reprogramming - physiology
/ Cold
/ Cold Shock Proteins and Peptides - chemistry
/ Cold Shock Proteins and Peptides - physiology
/ Gene Expression Regulation, Plant - physiology
/ Genes
/ Humanities and Social Sciences
/ Kinases
/ Mammals
/ Mosses
/ Plants, Genetically Modified
/ Protein Domains - physiology
/ Proteins
/ Science
