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Myelination and the trophic support of long axons
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Journal Article
Myelination and the trophic support of long axons
2010
Overview
Ensheathing glia are essential for the long-term survival of axons; however, the mechanisms by which they contribute to neuronal viability are unclear. Here, Nave proposes that long axons require continuous support from glia to meet their metabolic needs, especially when insulated by myelin.
In addition to their role in providing myelin for rapid impulse propagation, the glia that ensheath long axons are required for the maintenance of normal axon transport and long-term survival. This presumably ancestral function seems to be independent of myelin membrane wrapping. Here, I propose that ensheathing glia provide trophic support to axons that are metabolically isolated, and that myelin itself might cause such isolation. This glial support of axonal integrity may be relevant for a number of neurological and psychiatric diseases.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animal Genetics and Genomics
/ Animals
/ Axonal Transport - physiology
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Demyelinating Diseases - etiology
/ Demyelinating Diseases - physiopathology
/ Disease
/ Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
/ Humans
/ Injuries
/ Muscle
/ Nerve Degeneration - etiology
/ Nerve Degeneration - physiopathology
/ Nervous system (semeiology, syndromes)
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