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Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals
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Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals
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Journal Article
Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals
2012
Overview
After its discovery in 1990, blood oxygenation level-dependent (BOLD) contrast in functional magnetic resonance imaging (fMRI) has been widely used to map brain activation in humans and animals. Since fMRI relies on signal changes induced by neural activity, its signal source can be complex and is also dependent on imaging parameters and techniques. In this review, we identify and describe the origins of BOLD fMRI signals, including the topics of (1) effects of spin density, volume fraction, inflow, perfusion, and susceptibility as potential contributors to BOLD fMRI, (2) intravascular and extravascular contributions to conventional gradient-echo and spin-echo BOLD fMRI, (3) spatial specificity of hemodynamic-based fMRI related to vascular architecture and intrinsic hemodynamic responses, (4) BOLD signal contributions from functional changes in cerebral blood flow (CBF), cerebral blood volume (CBV), and cerebral metabolic rate of O2 utilization (CMRO2), (5) dynamic responses of BOLD, CBF, CMRO2, and arterial and venous CBV, (6) potential sources of initial BOLD dips, poststimulus BOLD undershoots, and prolonged negative BOLD fMRI signals, (7) dependence of stimulus-evoked BOLD signals on baseline physiology, and (8) basis of resting-state BOLD fluctuations. These discussions are highly relevant to interpreting BOLD fMRI signals as physiological means.
Publisher
SAGE Publications,Nature Publishing Group,Sage Publications Ltd
Subject
/ Biological and medical sciences
/ Cerebrovascular Circulation - physiology
/ Functional magnetic resonance imaging
/ Humans
/ Lipids (lysosomal enzyme disorders, storage diseases)
/ Magnetic Resonance Imaging - methods
/ Oxygen Consumption - physiology
/ Review
/ Vascular diseases and vascular malformations of the nervous system
