Asset Details
Do you wish to reserve the book?
Enteropathogenic Escherichia coli induces Entamoeba histolytica superdiffusion movement on fibronectin by reducing traction forces
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Enteropathogenic Escherichia coli induces Entamoeba histolytica superdiffusion movement on fibronectin by reducing traction forces
Do you wish to request the book?
Enteropathogenic Escherichia coli induces Entamoeba histolytica superdiffusion movement on fibronectin by reducing traction forces
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Enteropathogenic Escherichia coli induces Entamoeba histolytica superdiffusion movement on fibronectin by reducing traction forces
2025
Overview
Amebiasis, caused by Entamoeba histolytica , is a global health concern, affecting millions and causing significant mortality, particularly in areas with poor sanitation. Although recent studies have examined E. histolytica ’s interaction with human intestinal microbes, the impact of bacterial presence on the parasite’s motility, mechanical forces, and their potential role in altering invasiveness have not been fully elucidated. In this study, we utilized a micropillar-array system combined with live imaging to investigate the effects of enteropathogenic Escherichia coli on E. histolytica ’s motility characteristics, F-actin spatial localization, and traction force exerted on fibronectin-coated substrates. Our findings indicate that co-incubation with live enteropathogenic E. coli significantly enhances the motility of E. histolytica , as evidenced by superdiffusive movement—characterized by increased directionality and speed—resulting in broader dispersal and more extensive tissue/cell damage. This increased motility is accompanied by a reduction in F-actin-dependent traction forces and podosome-like structures on fibronectin-coated substrates, but with increased F-actin localization in the upper part of the cytoplasm. These findings highlight the role of physical interactions and cellular behaviors in modulating the parasite’s virulence, providing new insights into the mechanistic basis of its pathogenicity.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Actin
/ Analysis
/ Arrays
/ Bacteria
/ Complications and side effects
/ E coli
/ Entamoeba histolytica - metabolism
/ Entamoeba histolytica - microbiology
/ Entamoeba histolytica - physiology
/ Entamoebiasis - parasitology
/ Enteropathogenic Escherichia coli - pathogenicity
/ Enteropathogenic Escherichia coli - physiology
/ Humans
/ Hygiene
/ Medicine and Health Sciences
/ Motility
/ Practice
/ Research and Analysis Methods
/ Traction
We currently cannot retrieve any items related to this title. Kindly check back at a later time.