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Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model
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Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model
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Journal Article
Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model
2017
Overview
Purpose
To investigate whether dynamic contrast -enhanced MRI (DCE-MRI) can distinguish the type of liver nodules in a rat model with N-nitrosodiethylamine- induced cirrhosis.
Methods
Liver nodules in cirrhosis were induced in 60 male Wistar rats via 0.01 % N-nitrosodiethylamine in the drinking water for 35-100 days. The nodules were divided into three groups: regenerative nodule (RN), dysplastic nodule (DN), and hepatocellular carcinoma (HCC). DCE-MRI was performed, and parameters including transfer constant (K
trans
), rate constant (K
ep
), extravascular extracellular space volume fraction (V
e
), and initial area under the contrast concentration versus time curve (iAUC) were measured and compared.
Results
The highest K
trans
and iAUC values were seen in HCC, followed by DN and RN (all
P
< 0.05). The area under the receiver operating characteristic curve (AUROC) for DN and HCC were 0.738 and 0.728 for K
trans
and iAUC, respectively. The AUROC for HCC were 0.850 and 0.840 for K
trans
and iAUC, respectively. Ordinal logistic regression analysis showed that K
trans
had a high goodness of fit (0.970, 95 % confidence interval, 13.751-24.958).
Conclusion
DCE-MRI is a promising method to differentiate of liver nodules. Elevated K
trans
suggested that the nodules may be transformed into HCC.
Key points
•
DCE-MRI is promising for differentiating among RN, DN, and HCC
•
K
trans
and iAUC positively correlated with malignancy degree of liver nodules
•
Elevated K
trans
suggests that the nodules may be transformed into HCC
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Animals
/ Biopsy
/ Carcinoma, Hepatocellular - blood supply
/ Carcinoma, Hepatocellular - etiology
/ Carcinoma, Hepatocellular - pathology
/ Early Detection of Cancer - methods
/ Humans
/ Imaging
/ Liver Cirrhosis - chemically induced
/ Liver Cirrhosis - complications
/ Liver Neoplasms - blood supply
/ Magnetic Resonance Imaging - methods
/ Male
/ Medicine
/ Neovascularization, Pathologic - diagnostic imaging
/ Rats
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