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Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1
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Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1
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Journal Article
Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1
2001
Overview
Adenovirus type 2 (Ad2) imports its DNA genome through the nuclear pore complex (NPC) of cells in interphase for viral production. Here we identify the NPC-filament protein CAN/Nup214 as a docking site for incoming Ad2 capsids. Binding to CAN is independent of cytosolic factors. Capsids disassemble at NPCs to free their DNA for import. This process requires binding of nuclear histone H1 to the stably docked capsids and involves H1-import factors, restricting this irreversible process to the proximity of the nucleus. Our results provide a molecular mechanism for disassembly of Ad2 and reveal an unexpected function of histone H1 in virus-mediated DNA import.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
Active Transport, Cell Nucleus - physiology
/ alpha Karyopherins - metabolism
/ beta Karyopherins - metabolism
/ Biomedical and Life Sciences
/ DNA
/ DNA, Viral - pharmacokinetics
/ Genomes
/ Histones
/ Humans
/ Imports
/ Nuclear Pore Complex Proteins - immunology
/ Nuclear Pore Complex Proteins - metabolism
/ Protein Binding - physiology
/ Proteins
/ Viruses
