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Antibiotic resistance breakers: current approaches and future directions
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Journal Article
Antibiotic resistance breakers: current approaches and future directions
2019
Overview
Infections of antibiotic-resistant pathogens pose an ever-increasing threat to mankind. The investigation of novel approaches for tackling the antimicrobial resistance crisis must be part of any global response to this problem if an untimely reversion to the pre-penicillin era of medicine is to be avoided. One such promising avenue of research involves so-called antibiotic resistance breakers (ARBs), capable of re-sensitising resistant bacteria to antibiotics. Although some ARBs have previously been employed in the clinical setting, such as the β-lactam inhibitors, we posit that the broader field of ARB research can yet yield a greater diversity of more effective therapeutic agents than have been previously achieved. This review introduces the area of ARB research, summarises the current state of ARB development with emphasis on the various major classes of ARBs currently being investigated and their modes of action, and offers a perspective on the future direction of the field.
Publisher
Oxford University Press
Subject
/ Animals
/ Anti-Bacterial Agents - pharmacology
/ Bacterial Infections - drug therapy
/ beta-Lactamase Inhibitors - pharmacology
/ beta-Lactamase Inhibitors - therapeutic use
/ Biomedical Research - trends
/ Control
/ Drug resistance in microorganisms
/ Drug Resistance, Microbial - drug effects
/ Humans
/ Mice
/ Review
