Asset Details
Do you wish to reserve the book?
Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
Do you wish to request the book?
Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
2005
Overview
Genetic influences on behavior are complex and, as such, the effect of any single gene is likely to be modest. Neuroimaging measures may serve as a biological intermediate phenotype to investigate the effect of genes on human behavior. In particular, it is possible to constrain investigations by prior knowledge of gene characteristics and by including samples of subjects where the distribution of phenotypic variance is both wide and under heritable influences. Here, we use this approach to show a dissociation between the effects of two dopamine genes that are differentially expressed in the brain. We show that the
DAT1
gene, a gene expressed predominantly in the basal ganglia, preferentially influences caudate volume, whereas the
DRD4
gene, a gene expressed predominantly in the prefrontal cortex, preferentially influences prefrontal gray matter volume in a sample of subjects including subjects with ADHD, their unaffected siblings, and healthy controls. This demonstrates that, by constraining our investigations by prior knowledge of gene expression, including samples in which the distribution of phenotypic variance is wide and under heritable influences, and by using intermediate phenotypes, such as neuroimaging, we may begin to map out the pathways by which genes influence behavior.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Attention Deficit Disorder with Hyperactivity - genetics
/ Attention Deficit Disorder with Hyperactivity - pathology
/ Attention deficit disorders. Hyperactivity
/ Attention deficit hyperactivity disorder
/ Biological and medical sciences
/ Caudate Nucleus - physiology
/ Child
/ Dopamine Plasma Membrane Transport Proteins - genetics
/ Dopamine Plasma Membrane Transport Proteins - physiology
/ Heredity
/ Humans
/ Male
/ Medicine
/ Prefrontal Cortex - pathology
/ Prefrontal Cortex - physiology
/ Psychology. Psychoanalysis. Psychiatry
/ Receptors, Dopamine D4 - genetics
/ Receptors, Dopamine D4 - physiology
/ Siblings
