Asset Details
Do you wish to reserve the book?
Striatal origin of the pathologic beta oscillations in Parkinson's disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Striatal origin of the pathologic beta oscillations in Parkinson's disease
Do you wish to request the book?
Striatal origin of the pathologic beta oscillations in Parkinson's disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Striatal origin of the pathologic beta oscillations in Parkinson's disease
2011
Overview
Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations remain elusive. Here, using mathematical models, we find that robust beta oscillations can emerge from inhibitory interactions between striatal medium spiny neurons. The interaction of the synaptic GABAa currents and the intrinsic membrane M-current promotes population oscillations in the beta frequency range. Increased levels of cholinergic drive, a condition relevant to the parkinsonian striatum, lead to enhanced beta oscillations in the striatal model. We show experimentally that direct infusion of the cholinergic agonist carbachol into the striatum, but not into the neighboring cortex, of the awake, normal rodent induces prominent beta frequency oscillations in the local field potential. These results provide evidence for amplification of normal striatal network dynamics as a mechanism responsible for the enhanced beta frequency oscillations in Parkinson's disease.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
Action Potentials - drug effects
/ Action Potentials - physiology
/ agonists
/ Animals
/ Brain
/ Carbachol - administration & dosage
/ Cholinergic Agonists - administration & dosage
/ cortex
/ gamma-Aminobutyric Acid - physiology
/ ganglia
/ Humans
/ Mice
/ Modeling
/ Neurons
/ Parkinsonian Disorders - physiopathology
/ patients
/ rodents
