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Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention
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Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention
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Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention
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Journal Article
Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention
2011
Overview
Although the expression of the non-classical HLA class I molecule HLA-G was first reported to be restricted to the fetal-maternal interface on the extravillous cytotrophoblasts, the distribution of HLA-G in normal tissues appears broader than originally described. HLA-G expression was found in embryonic tissues, in adult immune privileged organs, and in cells of the hematopoietic lineage. More interestingly, under pathophysiological conditions HLA-G antigens may be expressed on various types of malignant cells suggesting that HLA-G antigen expression is one strategy used by tumor cells to escape immune surveillance. In this article, we will focus on HLA-G expression in cancers of distinct histology and its association with the clinical course of diseases, on the underlying molecular mechanisms of impaired HLA-G expression, on the immune tolerant function of HLA-G in tumors, and on the use of membrane-bound and soluble HLA-G as a diagnostic or prognostic biomarker to identify tumors and to monitor disease stage, as well as on the use of HLA-G as a novel therapeutic target in cancer.
Publisher
Basel : SP Birkhäuser Verlag Basel,SP Birkhäuser Verlag Basel,Springer Nature B.V,Springer Verlag
Subject
/ Animals
/ Antigens
/ Biomedical and Life Sciences
/ Cancer
/ Fetuses
/ Gene Expression Regulation, Neoplastic
/ Histocompatibility antigen HLA
/ Histocompatibility Antigens Class I
/ Histocompatibility Antigens Class I - genetics
/ Histocompatibility Antigens Class I - immunology
/ HLA-G
/ Humans
/ tissues
/ Tumors
