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Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes
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Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes
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Journal Article
Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes
2010
Overview
Clinical malaria is associated with the proliferation of Plasmodium parasites in human erythrocytes. The coordinated processes of parasite egress from and invasion into erythrocytes are rapid and tightly regulated. We have found that the plant-like calcium-dependent protein kinase PfCDPK5, which is expressed in invasive merozoite forms of Plasmodium falciparum, was critical for egress. Parasites deficient in PfCDPK5 arrested as mature schizonts with intact membranes, despite normal maturation of egress proteases and invasion ligands. Merozoites physically released from stalled schizonts were capable of invading new erythrocytes, separating the pathways of egress and invasion. The arrest was downstream of cyclic guanosine monophosphate-dependent protein kinase (PfPKG) function and independent of protease processing. Thus, PfCDPK5 plays an essential role during the blood stage of malaria replication.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ Calcium-Binding Proteins - chemistry
/ Calcium-Binding Proteins - genetics
/ Calcium-Binding Proteins - metabolism
/ Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors
/ Cyclic GMP-Dependent Protein Kinases - metabolism
/ Egress
/ Enzyme Inhibitors - pharmacology
/ Humans
/ Kinases
/ Ligands
/ Malaria
/ Pharmacology. Drug treatments
/ Plasmodium falciparum - cytology
/ Plasmodium falciparum - enzymology
/ Plasmodium falciparum - growth & development
/ Plasmodium falciparum - physiology
/ Protease
/ Protein Kinases - metabolism
/ Proteins
/ Protozoan Proteins - chemistry
/ Protozoan Proteins - genetics
/ Protozoan Proteins - metabolism
/ Recombinant Fusion Proteins - chemistry
