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Blastomyces dermatitidis produces melanin in vitro and during infection
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Journal Article
Blastomyces dermatitidis produces melanin in vitro and during infection
2004
Overview
Melanin is made by several important pathogenic fungi and is implicated in the pathogenesis of a number of mycoses. This study investigates whether the thermally dimorphic fungal pathogen
Blastomyces dermatitidis produces melanin. Using techniques developed to study melanization in other fungi, we demonstrate that
B. dermatitidis conidia and yeast produce melanin in vitro and that yeast cells synthesize melanin or melanin-like pigment in vivo. Melanization reduced susceptibility to amphotericin B, but not to itraconazole or voriconazole. Since melanin is an important virulence factor in other pathogenic fungi, this pigment may affect the pathogenesis of blastomycosis.
Publisher
Elsevier B.V,Blackwell Publishing Ltd,Blackwell,Oxford University Press
Subject
/ Amphotericin B - pharmacology
/ Animals
/ Antifungal Agents - pharmacology
/ Biological and medical sciences
/ Blastomyces - growth & development
/ Blastomycosis - microbiology
/ Conidia
/ Dogs
/ Fundamental and applied biological sciences. Psychology
/ Fungi
/ Humans
/ Melanin
/ Mycology
/ Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
/ Yeast
