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MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells
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MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells
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Journal Article
MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells
2012
Overview
The peroxisome proliferators-activated receptor (
PPAR)
γ pathway is involved in cancer, but it appears to have both tumor suppressor and oncogenic functions. In neuroblastoma cells, miR-27b targets the 3′ untranslated region of
PPAR
γ and inhibits its mRNA and protein expression. miR-27b overexpression or
PPAR
γ inhibition blocks cell growth
in vitro
and tumor growth in mouse xenografts.
PPAR
γ activates expression of the pH regulator
NHE1
, which is associated with tumor progression. Lastly, miR-27b through
PPAR
γ regulates nuclear factor-κB activity and transcription of inflammatory target genes. Thus, in neuroblastoma, miR-27b functions as a tumor suppressor by inhibiting the tumor-promoting function of
PPAR
γ, which triggers an increased inflammatory response. In contrast, in breast cancer cells,
PPAR
γ inhibits
NHE1
expression and the inflammatory response, and it functions as a tumor suppressor. We suggest that the ability of
PPAR
γ to promote or suppress tumor formation is linked to cell type-specific differences in regulation of
NHE1
and other target genes.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 3' Untranslated Regions - physiology
/ Animals
/ Cation Transport Proteins - physiology
/ Growth
/ Humans
/ Inflammation - prevention & control
/ Medicine
/ Mice
/ Neuroblastoma - prevention & control
/ Oncology
/ Peroxisome proliferator-activated receptors
/ PPAR gamma - antagonists & inhibitors
/ Sodium-Hydrogen Exchangers - physiology
/ Tumors
