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Stress-Related Noradrenergic Activity Prompts Large-Scale Neural Network Reconfiguration
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Stress-Related Noradrenergic Activity Prompts Large-Scale Neural Network Reconfiguration
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Stress-Related Noradrenergic Activity Prompts Large-Scale Neural Network Reconfiguration
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Journal Article
Stress-Related Noradrenergic Activity Prompts Large-Scale Neural Network Reconfiguration
2011
Overview
Acute stress shifts the brain into a state that fosters rapid defense mechanisms. Stress-related neuromodulators are thought to trigger this change by altering properties of large-scale neural populations throughout the brain. We investigated this brain-state shift in humans. During exposure to a fear-related acute stressor, responsiveness and interconnectivity within a network including cortical (frontoinsular, dorsal anterior cingulate, inferotemporal, and temporoparietal) and subcortical (amygdala, thalamus, hypothalamus, and midbrain) regions increased as a function of stress response magnitudes, β-adrenergic receptor blockade, but not cortisol synthesis inhibition, diminished this increase. Thus, our findings reveal that noradrenergic activation during acute stress results in prolonged coupling within a distributed network that integrates information exchange between regions involved in autonomic-neuroendocrine control and vigilant attentional reorienting.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science,American Association for the Advancement of Science (AAAS)
Subject
/ Adrenergic beta-Antagonists - pharmacology
/ Adrenergic Neurons - physiology
/ Adult
/ Affect
/ Amygdala
/ Autonomic Nervous System - physiology
/ Biological and medical sciences
/ Blocking
/ Brain
/ cortisol
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Human
/ Humanities and Social Sciences
/ Humans
/ Locus Coeruleus - physiology
/ Male
/ Networks
/ Neurons
/ Neurosecretory Systems - physiology
/ Neurotransmitter Agents - physiology
/ Placebos
/ Receptors, Adrenergic, beta - physiology
/ Stress
/ Stress, Psychological - physiopathology
/ Stress, Psychological - psychology
/ Stresses
/ Thalamus
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