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Binary Bacillus subtilis protects the intestinal mucosa barrier and alleviates nonalcoholic steatohepatitis
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Binary Bacillus subtilis protects the intestinal mucosa barrier and alleviates nonalcoholic steatohepatitis
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Journal Article
Binary Bacillus subtilis protects the intestinal mucosa barrier and alleviates nonalcoholic steatohepatitis
2024
Overview
Background Nonalcoholic steatohepatitis (NASH) is characterized by liver steatosis, inflammation, and even fibrosis. NASH is likely to develop into cirrhosis and liver cancer, the major causes of liver related deaths. We aimed to study the effect of probiotics on NASH via the gut‐liver axis. Methods Thirty male Sprague–Dawley rats were divided into three groups. A control group of 10 rats was fed on a standard chow for 16 weeks. Twenty rats fed on a high‐fat diet for 8 weeks were separated to two groups: a model group (10 rats) fed on vehicle for 8 weeks and a treatment group (10 rats) supplemented with binary Bacillus subtilis for 8 weeks. Hepatic expression of IL‐6 and TNF‐ɑ and ileum expression of IL‐17 and occludin were measured. Results The high‐fat diet caused inflammation of the liver and ileum in rats. Binary Bacillus subtilis treatment reduces liver inflammation through the intestinal liver axis. Increased levels of IL‐6 and TNF‐α were detected in rats fed a high‐fat diet, which were reduced to lower levels after treatment with binary Bacillus subtilis. In rats on the high‐fat diet, elevated IL‐17 levels and decreased occludin levels were observed. Treatment with Bacillus subtilis reduced IL‐17 levels and restored the expression of occludin. Conclusion Binary Bacillus subtilis has a beneficial effect on liver inflammation and intestinal damage. The gut liver axis has a functional connection between the gastrointestinal tract and the liver. Most of the blood in the liver comes from the intestines. Binary Bacillus subtilis is composed of 4.5 × 108 Fecal Escherichia coli R0026 and 5 × 107 Bacillus subtilis R0179. Binary Bacillus Subtilis treatment protect the intestinal mucosa barrier and alleviate enteritis and non‐alcoholic steatohepatitis.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
Subject
/ Diet
/ Diet, High-Fat - adverse effects
/ Fibrosis
/ Ileum
/ Intestinal Mucosa - drug effects
/ Intestinal Mucosa - metabolism
/ Intestinal Mucosa - microbiology
/ Intestinal Mucosa - pathology
/ Liver
/ Male
/ males
/ medicine
/ Non-alcoholic Fatty Liver Disease - metabolism
/ non‐alcoholic steatohepatitis
/ Original
/ Rats
/ Regular
