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The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer
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The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer
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Journal Article
The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer
2014
Overview
Background:
The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors for various types of cancer. In this study, we assessed the association of NLR and PLR with the prognosis of small-cell lung cancer (SCLC) in patients who received the standard treatment.
Methods:
We retrospectively reviewed patients who were diagnosed with SCLC and treated with platinum-based chemotherapy between July 2006 and October 2013 in Gyeongsang National University Hospital Regional Cancer Center and Changwon Samsung Hospital.
Results:
In total, 187 patients were evaluated. Compared with low NLR (<4), high NLR (⩾4) at diagnosis was associated with poor performance status, advanced stage, and lower response rate. Median overall survival (OS) and progression-free survival (PFS) were worse in the high-NLR group (high
vs
low, 11.17
vs
9.20 months,
P
=0.019 and 6.90
vs
5.49 months,
P
=0.005, respectively). In contrast, PLR at diagnosis was not associated with OS or PFS (
P
=0.467 and
P
=0.205, respectively). In multivariate analysis, stage, lactate dehydrogenase, and NLR at diagnosis were independent prognostic factors for OS and PFS.
Conclusions:
NLR is easily measurable and reflects the SCLC prognosis. A future prospective study is warranted to confirm our results.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Female
/ Humans
/ Lung Neoplasms - drug therapy
/ Male
/ Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
/ Oncology
/ Small Cell Lung Carcinoma - drug therapy
/ Small Cell Lung Carcinoma - immunology
/ Small Cell Lung Carcinoma - mortality
/ Tumors
