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PDGF-C is a new protease-activated ligand for the PDGF α-receptor
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PDGF-C is a new protease-activated ligand for the PDGF α-receptor
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Journal Article
PDGF-C is a new protease-activated ligand for the PDGF α-receptor
2000
Overview
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF α-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice.
In situ
hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF α-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ Epithelial Cells - chemistry
/ Epithelial Cells - enzymology
/ Epithelial Cells/chemistry/enzymology
/ Gene Expression - physiology
/ Gene Expression Regulation, Developmental
/ Heart
/ Humans
/ Insecta
/ Insects
/ Kidney/chemistry/embryology/enzymology
/ Ligand binding (Biochemistry)
/ Ligands
/ Mesoderm/chemistry/enzymology
/ Mice
/ Myocardium/chemistry/enzymology
/ Platelet-Derived Growth Factor - chemistry
/ Platelet-Derived Growth Factor - genetics
/ Platelet-Derived Growth Factor - metabolism
/ Platelet-Derived Growth Factor - pharmacology
/ Platelet-Derived Growth Factor/chemistry/genetics/metabolism/pharmacology
/ Rabbits
/ Receptor, Platelet-Derived Growth Factor alpha - metabolism
